But who has been romantically linked to the "Family Guy" funnyman, you ask?
Here are a few of Mac Farlane's past love interests.
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, her relationship with the then 17-year-old cooled as soon as they tried to turn up the heat.
Wrote O'Neal, "I was just 12 and not at all ready for a real-life encounter ...
and the lurid details that arose from their 2004 romance.
Rumors circulated that the 20-year-old Johansson enjoyed a romp in the elevator of the Chateau Marmont with the 37-year-old del Toro following the Oscars.
The actress, however, has since denied the rumors, insisting she only goes down in elevators to get to the bottom floor., the duo called it quits in 2006.
A source told Us Weekly that "Project X" actress Alexis Knapp, who has a daughter with ex-boyfriend Ryan Phillippe, was hooking up with Mac Farlane in early 2012 and began seeing the "Ted" director while she was still pregnant.
Mac Farlane was seen flirting with "Twilight" star Ashley Greene at LA's Chateau Marmont in April 2009, according to Us Weekly.